first_img Top Stories Comments   Share   Grace expects Greinke trade to have emotional impact The 5: Takeaways from the Coyotes’ introduction of Alex Meruelo – / 17 Derrick Hall satisfied with D-backs’ buying and selling Former Cardinals kicker Phil Dawson retires “I almost passed out,” Cardinals cornerback Patrick Peterson said of the total. “That is unacceptable for us, especially for our standards. We have been playing so well all year and to have that performance tonight, it is embarrassing.”It certainly wasn’t anything to brag about.The Cardinals allowed 10 plays of 20 or more yards, including touchdowns that went for 80, 20 and 79 yards. They couldn’t stop Seattle quarterback Russell Wilson’s arm or his legs, and toward the end of the game, they struggled to contain running back Marshawn Lynch. Arizona allowed the majority of the yards (305) in the first half, but surrendered 21 of the points in the second. GLENDALE, Ariz. — It may have been an unfair request, but that doesn’t change the fact that the Arizona Cardinals needed their defense to step up in a big way Sunday night against the Seattle Seahawks.Instead, they pretty much stepped aside as the visitors posted a franchise-record 596 net yards en route to a 35-6 romp. That total is tied for the second-most yards allowed in Cardinals history, by the way.last_img read more

first_img Source:https://newsroom.uw.edu/news/researchers-classify-alzheimers-patients-6-subgroups Reviewed by James Ives, M.Psych. (Editor)Dec 5 2018Researchers studying Alzheimer’s disease have created an approach to classify patients with Alzheimer’s disease, a finding that may open the door for personalized treatments.”Alzheimer’s, like breast cancer, is not one disease,” said lead author Shubhabrata Mukherjee, research assistant professor in general internal medicine at the University of Washington School of Medicine. “I think a good drug might fail in a clinical trial because not all the subjects have the same kind of Alzheimer’s.This study, published in the recent issue of Molecular Psychiatry, involves 19 researchers from several institutions, including Boston University School of Medicine, the VA Puget Sound Health Care System and Indiana University School of Medicine.The researchers put 4,050 people with late-onset Alzheimer’s disease into six groups based on their cognitive functioning at the time of diagnosis and then used genetic data to find biological differences across these groups.”The implications are exciting,” said corresponding author Paul Crane, professor of general internal medicine at the University of Washington School of Medicine. “We have found substantial biological differences among cognitively defined subgroups of Alzheimer’s patients.”Identification of cognitive subgroups related to genetic differences is an important step toward developing a precision medicine approach for Alzheimer’s disease.The participants received cognitive scores in four domains: memory, executive functioning, language, and visuospatial functioning.The largest group (39%) had scores in all four domains that were fairly close to each other. The next largest group (27%) had memory scores substantially lower than their other scores. Smaller groups had language scores substantially lower than their other scores (13%), visuospatial functioning scores substantially lower than their other scores (12%), and executive functioning scores substantially lower than their other scores (3%). There were 6% who had two domains that were substantially lower than their other scores.Related StoriesCancer killing capability of lesser-known immune cells identifiedSugary drinks linked to cancer finds studyHealthy lifestyle lowers dementia risk despite genetic predispositionThe participants came from five studies, and it took more than two years to standardize the neuropsychological test scores across all the studies in order to detect meaningful patterns. The mean age was 80, 92 percent self-reported white race, and 61 percent were female.The investigators used genome-wide genetic data to find out if the subgroups are biologically distinct.Investigators found 33 single nucleotide polymorphisms (SNPs) – specific locations throughout the genome – where the genetic association was very strong for one of the subgroups. These genetic relationships were stronger than the strongest effects found by an earlier and much larger international consortium study where Alzheimer’s disease was treated as a single homogeneous condition.Several years ago, the International Genomics of Alzheimer’s Project Consortium published the largest genome-wide association study of Alzheimer’s disease and found about 20 SNPs associated with Alzheimer’s disease risk.This study found 33 additional SNPs with even stronger relationships with a single subgroup.The study also found a particularly strong relationship between a particular variant of the APOE gene and risk for the memory subgroup. The APOE e4 allele is a very strong risk factor for developing Alzheimer’s disease for people with European ancestry, and it also appears to influence which cognitive subtype of Alzheimer’s a person is likely to develop.People can currently find out if they have an APOE e4 allele with direct-to-consumer testing; however, the researchers note that many people with an APOE e4 allele never develop Alzheimer’s disease, and many who don’t carry any known genetic risk factor nevertheless end up with the condition.While world leaders want to find a cure for Alzheimer’s by 2025, so far no one has been able to develop an effective treatment let alone a cure. But this study suggests that thinking of Alzheimer’s disease as six distinct conditions may provide a way forward.”This study is not the end, it’s a start,” said Mukherjee.​last_img read more

first_img Source:https://www.jhsph.edu/news/news-releases/2019/breast-cancer-patients-weigh-in-on-addressing-financial-burdens.html Reviewed by James Ives, M.Psych. (Editor)Mar 8 2019A qualitative study led by researchers at the Johns Hopkins Bloomberg School of Public Health yielded nine patient-driven recommendations across circumstances that include changes to insurance, supportive services and financial assistance to reduce long-term, breast cancer-related economic burden.The study appears online March 6 in the journal Cancer.U.S. breast cancer patients experience considerable economic burdens compared with those who have other types of cancer. The financial burdens are often exacerbated for patients who are managing treatment side effects, particularly breast cancer-related lymphedema, swelling of the arms or torso commonly caused by the removal of the lymph nodes during breast cancer surgery.Over 250,000 new breast cancer cases are diagnosed each year in the U.S. Lymphedema affects nearly 35 percent of U.S. breast cancer survivors, and results in an estimated $14,877 in out-of-pocket costs in the first two years of a diagnosis for patients who develop lymphedema. Previous research suggests that 10 years post-diagnosis, breast cancer survivors with lymphedema have over double the health care costs as those not affected by lymphedema.”No one should have to make a choice between their health and their money. Yet breast cancer survivors face incredibly high prices that can lead to severe financial hardships, even bankruptcy,” says lead author Lorraine T. Dean, ScD, assistant professor in the Bloomberg School’s Department of Epidemiology. “These recommendations offer ways to adapt a range of policies and practices that would make it more likely that breast cancer survivors can afford and attain the care they need.”Previous studies of breast cancer patients focused on provider and insurer perspectives on reducing costs, but not the patient, notes Dean. “This study offered breast cancer survivors a voice to tell us what they think should be done to make their lives better,” says Dean.For the study, interviews were conducted with 40 long-term breast cancer survivors from New Jersey and Pennsylvania in 2015. Participants were chosen to ensure a range of ages, lifestyles and severity of lymphedema. Of the 40 participants, 24 had lymphedema. The interviews were designed to better understand the financial problems participants faced after cancer, what types of issues they may have had with insurers, who they asked for help and what they thought should happen so that future breast cancer survivors could avoid high costs.The interviewees offered nine actionable recommendations: Provide assistance with understanding what is covered under insurance and how to navigate changes when switching to a new insurance provider Ensure high-quality insurance that covers required and elective cancer services with low co-pays, premiums and deductibles Expand insurance coverage for lymphedema-specific supplies and lymphedema management, including long-term physical therapy and complementary and alternative medical treatments Address psychosocial costs by expanding support groups and buddy services Expand the availability of home health care services after cancer treatment Provide domestic assistance with household chores, child care and transportation Expand eligibility for financial aid and social services to those who are not in poverty Provide financial counseling or navigation throughout the diagnosis and treatment process Expand policies that protect employment and medical leave to offer more acceptable leave timecenter_img Related StoriesHow cell-free DNA can be targeted to prevent spread of tumorsNew study to ease plight of patients with advanced cancerCancer killing capability of lesser-known immune cells identifiedPrevious recommendations included affordable insurance, prompt information on costs and access to financial navigation and peer support. In this study, recommendations include institutional changes and policies that patients see as setting or driving costs.Patient-driven recommendations to keep insurance costs low have been criticized for potentially driving up costs for insurers. As a counter argument, the authors offer an example: In one state, expanding coverage for lymphedema services and treatment lowered patient out-of-pocket costs and lymphedema-related hospitalizations, while having a less than 0.1 percent impact on costs for insurance claims and less than a 0.2 percent impact on insurance premiums after 10 years.Several states (California, Louisiana, Maryland, North Carolina and Virginia) have passed legislation that expands lymphedema treatment coverage under existing insurance. Congress has considered, but not yet passed, legislation that would do the same across the nation.Survey participants offered several ideas for changes to private business services and nonprofits. For example, mortgage deferment services, which are currently used for other reasons besides health, could be used to reduce expenses that could then be used for cancer treatment.While many nonprofits currently have charitable assistance programs, study participants suggested that eligibility for assistance be determined by whether or not the patient has access to additional resources, rather than on poverty guidelines. Additionally, physicians and health providers could make referrals for financial counseling services during the course of care.The researchers suggest that without changes, the out-of-pocket costs will continue to pose a challenge for the growing number of breast cancer survivors in the U.S.last_img read more

© 2018 AFP Citation: Boeing reports jump in 1Q profits, lifts 2018 forecast (2018, April 25) retrieved 18 July 2019 from https://phys.org/news/2018-04-boeing-1q-profits.html The aerospace giant reported that earnings surged 56.9 percent from the first three months of 2017, rising to $2.5 billion. Revenues rose 6.5 percent to $23.4 billion.The upbeat report sent the company’s share price higher, and reflects the health of the airline industry as flying becomes much more common in the Middle East, Asia and other developing regions.A big player in China, Boeing has often been seen as vulnerable to a trade war between Washington and Beijing, a possibility that topped Wall Street’s list of worries earlier this month but has receded of late amid softer rhetoric between and the prospect of talks in coming days.Boeing chief executive Dennis Muilenburg said he was encouraged that the US planned to send a high-level trade team to Beijing. President Donald Trump confirmed Tuesday that Treasury Secretary Steven Mnuchin, US Trade Representative Robert Lighthizer will travel to China soon.”We know aerospace is very important to both countries and while some initial statements have been made about potential tariffs, none of those severe actions have been implemented,” Muilenburg said on a conference call with analysts and reporters. “And we’re frankly encouraged by the continuing dialogue and we’ve heard from leadership in both countries that both are seeking to find negotiated positions that will be productive for both countries.”Muilenburg said Boeing’s supply chain had not been significantly affected by tariffs on aluminum and other measures that have been implemented.Cargo demand risingIn the quarter ending March 31, Boeing notched higher commercial plane deliveries compared with the year-ago period. Planes with gains included the narrow-aisle 737 and the 787 “Dreamliner.” The aerospace giant has been consulting with customers on launching a possible “middle market” plane that would fall between its narrow-body model, which carries up to 200 people, and its wide-body design, which typically flies around 300.The company said it would raise production for the Boeing 767 plane to three a month from 2.5 due to strength in the cargo market as industrial demand picks up.Earnings in Boeing’s defense division were lifted by strong weapons volume. The company won new business from Kuwait and said it was on track with the KC-46 tanker program, a US Air Force transport aircraft contract that has led to unexpected cost increases in prior quarters.A report earlier this month by the US Government Accountability Office warned that deliveries of the first fully capable KC-46 tankers could slip to May 2019 from the current timetable of October 2018, citing a number of risks to the timeframe that need to be mitigated.But Muilenburg said the company was making “steady progress” on the project and towards delivering the first 18 tankers this year.Iranian deliveries delayedOther key questions surrounding Boeing include the status of talks with Brazilian company Embraer on a potential collaboration that must be blessed by the government in Brasilia.Boeing also could be impacted if President Donald Trump scotches the nuclear agreement between Iran and major governments that opened the door to commercial plane sales in the sanctions-constrained country.Muilenburg said Boeing has delayed deliveries of 777 planes to Iran in line with the US government process and its targets for 2018 had not accounted for them.”The plan that we outlined for your is not dependent on the Iranian orders,” he said. “If those orders do come to fruition, if we do ultimately deliver airplanes, those represent opportunities for us.” Shares climbed 2.3 percent to $336.58 in midday trading, the biggest gainer in the Dow. Boeing profits jumped, and the company upgraded its earnings forecast for this year Wednesday amid a strong commercial aviation market and as executives expressed optimism the US and China will avoid a trade war. Explore further This document is subject to copyright. Apart from any fair dealing for the purpose of private study or research, no part may be reproduced without the written permission. The content is provided for information purposes only. High product, labor costs lead to decline in Boeing’s profit The Boeing logo on the first Boeing 737 MAX 9 airplane is pictured during its rollout for media in March 2017 read more